Hi,
If you change address in PO header manually, a new address number will be generated which will be updated in EKKO-ADRNR field and the same will be available in ADRC table. But it wont update any address data automatically in standard.
If the address change in PO update the master data, refer the note: 821981 - Change in Vendor Address in PO updates Vendor Master address
If the note is not relevant to your release / issue is not resolved, revert back with your SAP release with EHP.
Regards,
AKPT